???? ?????? ?? ???? ???? ?????? ????? ???? ?? ???? ???? ???? ??? ??????? ??? ??? ???? ????? ??????? ???? ???? ??????.???? ????? ??? ??? ????? ?? ?? ??????? ???????: ????? ????? ? ?????, ??? ??? ????? ?? ????? ?? ??????, ??? ?????.The dosing tips under, therefore, can only be considered as proposed strategies to what is definitely a number of clinic